But Ireland, who stopped England winning the Grand Slam on the final day of the 2017 tournament, could have the tables turned on them at Twickenham this weekend if Jones can avoid a third straight loss.
But Ireland have not won a Grand Slam since 2009, when Ronan O’Gara dropped a goal in Cardiff with just two minutes left against Wales to win the final game and secure their first clean sweep for 61 years – so there will be little need for added motivation on St Patrick’s Day in London.
So here’s everything you need to know about the game.
England vs Ireland kickoff time and TV channel
England and Ireland will be the middle fixture of so-called “Super Saturday”, when all six teams play on one day for the only time in the tournament.
The game will kick off at 2.45pm and be live on ITV with coverage starting at 2.25pm.
England vs Ireland live stream
The Six Nations coverage for 2018 has been split between ITV and the BBC once again.
Since both channels are terrestrial and free-to-air, every game of the Six Nations will be shown live online for free.
To watch England vs Ireland online, viewers simply need to hold a valid TV licence and may be required to sign in to the ITV website to stream the match.
England team vs Ireland
Starting XV: Anthony Watson, Jonny May, Jonathan Joseph, Ben Te’o, Elliot Daly; Owen Farrell, Richard Wigglesworth; Mako Vunipola, Dylan Hartley, Kyle Sinckler, Maro Itoje, George Kruis, Chris Robshaw, James Haskell, Sam Simmonds.
Replacements: Jamie George, Joe Marler, Dan Cole, Joe Launchbury, Don Armand, Danny Care, George Ford, Mike Brown.
Ireland team vs England
Starting XV: Rob Kearney, Keith Earls, Garry Ringrose, Bundes Aki, Jacob Stockdale; Johnny Sexton, Conor Murray; Cian Healy, Rory Best, Tadgh Furlong, James Ryan, Iain Henderson, Peter O’Mahony, Dan Leavy, CJ Stander.
Replacements: Sean Cronin, Jack McGrath, Andrew Porter, Devin Toner, Jordi Murphy, Kieran Marmion, Joey Carbery, Jordan Larmour.
England vs Ireland odds
Result: England evens, Ireland 11/10
Match handicap: England -0.5
First try-scorer: Jacob Stockade 15/2, Elliot Daly 9/1, Jonny May 9/1, Anthony Watson 10/1, Keith Earls 10/1, Jordan Larmour 10/1.